Diazepam Tablets 10mg is an efficacious medicine which belongs to a group of drugs called benzodiazepines. Diazepam Tablets are used in treating anxiety disorders, panic disturbances, and sleep-related disorders extensively.
United States Patent 3,520,878 PREPARATION OF DIAZEPAM John Brammer Petersen, Haifa, Israel, assignor to W. R. grafie & Co., New York, N.Y., a corporation of New or No Drawing. Continuation-impart of application Ser. No. 579,500, Sept. 15, 1966. This application Oct. 15, 1968, Ser. No. 767,838 Claims priority, application Denmark, Sept. 17, 1965,
Int. cl. C07d 53/06 US. Cl. 260-2393 7 Claims ABSTRACT OF THE DISCLOSURE In abstract, this invention is directed to a process for preparing diazepam, comprising subjecting 2- (2-azido-N- methylacetamido) 5 chlorobenzophenone to reductive cyclization, and recovering the thus formed diazepam, all as recited hereinafter.
BACKGROUND OF THE INVENTION This invention is in the field of diazepam preparation. Diazepam which has the formula SUMMARY OF THE INVENTION In summary, this invention is directed to a process for preparing 7 'chloro 1,3-dihydro-l-methyl-S-phenyl-ZH- 1,4-benzodiazepin-2-one which comprises reacting 2-(2- azido-N-methylacetamido)-5 chlorobenz ophenone with a cyclizing reducing agent selected from the group consisting of hydrogen and hydrazine hydrate in the presence of a Group VIII metal catalyst, separating, and recovering the 7 chloro 1,3-dihydro-l-methyl-S-phenyl-ZH- 1,4-benzodiazepin-2-0ne formed thereby.
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