Codeine Tablets 60mg
Codeine tablets 60 mg are generally an opiate which is used to treat cough, diarrhea and a mild degree of pain. It is a narcotic pain-reliever and cough suppressant similar to morphine and hydrocodone. Moreover, a small amount of codeine is converted to morphine in the body.
Albert Frey, Riehen, near Basel, and Edna Moritz Wiiest, Arlesheim, near. Basel, Switzerland, assignors to Hoffman-La Roche Inc., Nutley, N. J a corporation of New Jersey -No Drawing. Application April s, 1936, Serial -No. 72,660. In Switzerland, June 7, 1935, 4 Claims; (01. 260-285) The problem of isolating the opium alkaloids directly from the ripe or unripe poppy plants'instead of from the dried latex of the poppy has repeatedly been the object of investigation. Various patents have been issued which cover processes for obtaining the opium alkaloids directly from the poppy plant (German Patents 232,126, 524,964, French Patent 748,308).
The reverse process, that is to say, the extraction of the alkaloids from the dilute solutions appeared to be impracticable and was consequently not attempted, because the formation of emulsions and the simultaneous passage of the impurities and alkaloids into the organic solvent used for the extraction was to be expected.
It has now been found that the extraction of the alkaloids from the enormous excess of an aqueous solvent and their separation from the large quantities of impurities with suitable organic solvents can be carried out in a technically economical and easy manner and that thereby yields are obtained which greatly exceed those of the technical methods used heretofore.
The acid or neutral aqueous extracts of ripe or unripe poppy plants or portions thereof are brought to a pH of about 9 by the addition of weak alkalis such as sodium or ammonium carbonate, or in the case of aqueous-alkaline extracts by the addition of acids. From the solutions treated in this way, the alkaloids are extracted with organic solvents which dissolve morphine and codeine and easily release these alkaloids again, such as chloroform, butanol, amyl alcohol and the like, or with mixtures of such solvents. Morphine and codeine are taken up by the solvent. Without the formation of emulsions and without admixture with any considerable quantities of impurities. From the organic solvent, the alkaloids may be obtained in the usual manner, for instance by transformation into concentrated aqueous alkaloid salt solutions by stirring with dilute acids and precipitating the alkaloids. After removal of the alkaloids, the organic solvent is almost free from impurities and may be used for further extractions without distillation. It is possible in this way with the aid Up to now of small quantities of organic solvent to extract 7 the alkaloids completely and in a very economical manner in spite of the great dilution in which they are present and of the generally rather unfavourable distribution-coefficient of morphine between water and organic solvents.
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