Tramadol Tablets

Tramadol tablets 50 mg are a strong sleeping drug used for the treatment of sleeplessness and pain-related disorders. These disorders can be caused by severe injury, medical surgery or panic disturbances. Tramadol tablets belong to a group of drugs called opiate narcotics analgesics. Tramadol tablets decrease the transmission of pain signals into the central nervous system& help in relaxing the brain cells and inducing quality sleep. Tramadol 50mg pills are one of the best sleep aids because of its instant pain relieving mechanism. Tramadol sleeping tablets can be easily swallowed and available in capsules and injection form as well.

Patent Information

The present invention relates to a controlled release preparation for oral administration, to processes for its preparation and to its medical use. In particular, (lie invention relates to a controlled release preparation comprising tramadol or a pharmaceutically acceptable salt thereof.

Tramadol, which has the chemical name (+)-trans-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol, is an orally active opioid analgesic. Conventional release preparations in the form of capsules, drops and suppositories containing tramadol, or more particularly its hydrochloride salt, have been commercially available for many years for use in the treatment of moderate to severe pain; Such preparations, however, do not provide a controlled release of the tramadol. Moreover, despite tramadol's long-standing use, controlled release preparations for oral administration containing tramadol as an active ingredient have not even previously been described in the literature.

It is an object of the present invention to provide an oral controlled release tramadol preparation suitable for at least twelve-hourly (e.g. up to twenty-four hourly) administration for the treatment of pain.

The present invention, therefore, provides a controlled release preparation comprising tramadol or a pharmaceutically acceptable salt thereof for oral administration.

Suitable pharmaceutically acceptable salts of tramadol for use according to the present invention are those conventionally known in the art such as pharmaceutically acceptable acid addition salts. The hydrochloride salt is particularly preferred.
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