What is Zolpidem (Ambien)?
Zolpidem, marketed under the brand name Ambien
, is a sleeping aid used to treat insomnia in the short term. According to the guidelines, you should only take it after cognitive behavioral therapy for insomnia and behavioral improvements such as sleep hygiene had explored.
This drug was licensed as a sedative and hypnotic in the United States (US) in 1992 as a . The popularity of this sedative drug has continued on the rise for over a decade. This medicine is frequently given for sleep-related issues in Europe and the United States, with millions of prescriptions filed each year. This figure topped the charts in 2017, making Ambien the 50th most commonly prescribed pharmaceutical across a wide range of drugs and categories.
Insomnia affects 10-30% of the adult population, according to several studies conducted around the world. It might be as high as 50-60 percent in extreme cases. Given that this is one of the most common causes of poor sleep hygiene, it's no surprise that sleep medications like zolpidem (generic name) had widely used.
How Does Ambien Work?
Zolpidem, often known as Ambien, reduces brain activity and allows you to sleep. The immediate-release formulation dissolves quickly, allowing you to fall asleep quickly. The extended-release version has two layers: one that helps you fall asleep and another that progressively dissolves to help you stay asleep.
GABA (gamma-aminobutyric acid) is the central nervous system's primary neurotransmitter (CNS). This medication is a GABAA receptor chloride channel modulator, enhancing GABA's inhibitory activity and providing soothing effects.
This non-method benzodiazepine of action is specific for omega-1 receptors. The alpha one subunit is present in these GABAA receptor subtypes. It's possible that this sedative's clinical profile, mainly its safety and efficacy, is due to its intrinsic solid activity and selectivity for omega-1 receptors.
As a non-benzodiazepine hypnotic. This medication's sedative effects take precedence over its anxiolytic, anticonvulsant, and myorelaxant actions. According to research, this medication can reduce the frequency of nightly awakenings and enhance sleep latency and duration in people with chronic insomnia. It also works as a moderate muscle relaxant (Bouchette et al., 2020).
What is the Purpose of Zolpidem/Ambien?
zolpidem sleeping pills are drugs used to treat insomnia (when you might have trouble getting to sleep and staying asleep). It makes it easier to fall asleep and less likely for you to wake up during the night.
The most prevalent sleep condition, insomnia, is characterized by early morning awakenings, difficulty falling asleep, fatigue throughout the day, and mental cognitive deficits. Insomnia can be acute (short-term, lasting a few days to weeks) or chronic (lasting several months or years, as seen in chronic patients).
The repercussions of insomnia can be harmful physically, emotionally, and cognitively, regardless of how long it lasts. Zolpidem tartrate is an FDA-approved sleeping pill that can help you sleep better.
This medicine's anti-anxiety, muscle relaxant, and anti-convulsant qualities lead to further usage. These side effects are minimal or secondary to Zolpidem's sedative effects.
What is the best way to take Zolpidem?
Take Zolpidem right before bed when you're ready to sleep or have problems falling asleep. This drug is quite effective in putting you to sleep quickly. Completely swallow the extended-release tablet. It should not be divided, crushed, or chewed.
Zolpidem had administered in the same manner as other sleep medications.
- By mouth, take the sedative tablets.
- Drink plenty of water. If you do so, the drug may move from your mouth to your stomach and then to your small intestines. It allows the active chemicals to be absorbed and the intended effects. Swallowing the tablets without enough water may cause the treatment to malfunction.
- You should take the drug in its original form. Crushing, chewing, or breaking up the pill in any manner may impair the therapeutic effect.
- It's best if you take the medication first thing in the morning. When taken with a meal or right after, You may speed up the start of the effect.
- Use this sleep aid an hour before bedtime and only when you have enough time to sleep (a whole night's sleep is 7 to 8 hours). The suggested dose for insomnia in ordinary adults is 10 mg.
- The administration should be done in a single sitting, not many times on the same treatment night.
- The average treatment time ranges from 2 to 4 weeks.
- After the benefits have worn off, the sedative effects may linger. It can induce cognitive difficulties. Therefore, it's best to avoid doing anything that requires them to operate machinery or drive. When combined with alcohol or other drugs with a similar effect, you may amplify these effects.
Is Zolpidem classified as a benzodiazepine?
Zolpidem is a benzodiazepine that works by binding to the BZ1 benzodiazepine receptor family component. Zolpidem is not an anticonvulsant or a muscle relaxant.
Benzodiazepines are a group of chemicals that have a benzene ring fused to a diazepine ring in their chemical structure. The pharmacodynamics of benzodiazepines are almost identical to those of non-benzodiazepines. Therefore, the benefits and risks of side effects are similar. These classifications, however, have diverse chemical structures and are thus unconnected on a molecular level.
It was one of the first three nonbenzodiazepine drugs approved for use. You discovered these drugs in the late 1980s and early 1990s. They had created to address some of the drawbacks of benzodiazepines, such as their long-lasting side effects and slow onset of action.
Nonbenzodiazepines are comparable to benzodiazepines; however, they have a higher level of safety. Non-benzodiazepines had regarded as safer than benzodiazepines for people with respiratory problems because they cause minimal respiratory depression.
Because several of the medications' names begin with the letter "Z," nonbenzodiazepines are referred to as "Z-drugs." This class also has fewer side effects than benzodiazepines when it comes to sleep induction, and it does not impair sleep architecture as much as the kind listed above. It corresponds to treatments that provide long-term benefits even when administered for a short period, significantly benefiting patients with insomnia and related symptoms.